Leprosy in pre-Norman Suffolk, UK: biomolecular and geochemical analysis of the woman from Hoxne.

PURPOSE: A woman's skull, exhibiting features of lepromatous leprosy (LL), was recovered from a garden in Hoxne, Suffolk. The absence of post crania and lack of formal excavation meant that diagnosis and dating was uncertain. The aim of this research was to confirm the diagnosis using biomolecular means and second, to place it in context with other British leprosy cases using SNP genotyping and radiocarbon dating. METHODOLOGY: Bone from the skull was analysed by ancient DNA (aDNA) methods and subjected to radiocarbon dating. As a result, stable carbon and nitrogen isotope values were produced, both useful for assessing aspects of the woman's diet.Results/Key findings. aDNA confirmed the presence of mycobacterium leprae and genotyping demonstrated an ancestral variant of subtype 3I, the same lineage recently identified in living squirrels in the south of England. Radiocarbon dating revealed the woman lived approximately between 885-1015 AD, providing evidence for endurance of this subtype in East Anglia, having been previously identified as early as the fifth-sixth century (Great Chesterford) and as late as the thirteenth century (Ipswich). CONCLUSIONS: The confirmation of a new pre-Norman leprosy case in East Anglia is of interest as this is where a high proportion of cases are located. Possible factors for this may include preservation and excavation biases, population density, but also connection and trade, possibly of fur, with the continent. Future research on other British LL cases should focus on exploring these aspects to advance understanding of the disease's history, here and on the continent.

Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy.

We have examined a 5th to 6th century inhumation from Great Chesterford, Essex, UK. The incomplete remains are those of a young male, aged around 21-35 years at death. The remains show osteological evidence of lepromatous leprosy (LL) and this was confirmed by lipid biomarker analysis and ancient DNA (aDNA) analysis, which provided evidence for both multi-copy and single copy loci from the Mycobacterium leprae genome. Genotyping showed the strain belonged to the 3I lineage, but the Great Chesterford isolate appeared to be ancestral to 3I strains found in later medieval cases in southern Britain and also continental Europe. While a number of contemporaneous cases exist, at present, this case of leprosy is the earliest radiocarbon dated case in Britain confirmed by both aDNA and lipid biomarkers. Importantly, Strontium and Oxygen isotope analysis suggest that the individual is likely to have originated from outside Britain. This potentially sheds light on the origins of the strain in Britain and its subsequent spread to other parts of the world, including the Americas where the 3I lineage of M. leprae is still found in some southern states of America.

[About a note published in 1926 on a BCG vaccine trial in leprosy treatment]. / À propos d'une note de 1926 sur un essai du BCG dans le traitement de la lèpre.

By 1926, two French physicians working in Indochina, R. Pons and L. Chastel, have suggested to treat leprosy by subcutaneous injections of bacillus Calmette-Guerin. This treatment appeared efficient since the lepromatous lesions quickly regressed and the Hansen bacillus disappeared from the nasal mucus. These results were quickly confirmed by other authors. They were all more appreciated than, at this time, the Chaulmoogra oil and its products, the only available drugs, were poorly efficient against the disease. Nevertheless, although not a panacea, the BCG therapy allowed to relieve these unfortunate patients until the beginning of the 1950's when an effective treatment by sulfones was at length available.

Tuberculosis pulmonar en un paciente con lepra lepromatosa: presentación de un caso / Pulmonary tuberculosis in a patient with lepromatous leprosy: presentation of a case

La tuberculosis y la lepra fueron enfermedades prevalentes durante el primer milenio en Europa, pero ya después, la lepra disminuyó en frecuencia. Por su parte, la tuberculosis se señala en un tercio de la población mundial, reportándose cada año diez millones de casos nuevos, a la vez que mueren tres millones de los existentes. La lepra, aunque se plantea, que está en vías de extinción, aún afecta a un millón de personas de países, para un 1 por ciento de prevalencia. En la actualidad, en muy raras ocasiones coinciden estas patologías. El objetivo de este trabajo fue mostrar el caso de un paciente con una lepra lepromatosa, que poco tiempo después de tratado por esta enfermedad, desarrolló una tuberculosis pulmonar. Para lograr lo propuesto se relacionó el estudio clínico y de laboratorio practicado al enfermo y se mostraron fotografías ilustrativas de ambos procesos. Luego de la revisión de la literatura, se llegó a la conclusión que estas entidades cuando coinciden en un solo sujeto son inusuales, y no han sido reportadas en Cuba(AU)

Tuberculosis and leprosy were prevalent diseases during the first millennium in Europe, but then leprosy decreased in frequency. On the other hand, tuberculosis affects a third of the world population, reporting ten millions of new cases every year, and dying three millions of them. Leprosy, which is considered in extinction, still affects a million of persons, for 1 per cent of prevalence. Nowadays, these diseases rarely coincide. The objective of this work was showing the case of a patient with lepromatous leprosy who, shortly after being treated for this disease, developed pulmonary tuberculosis. To achieve our proposal we made a relation of the clinical and laboratory study of the patient and showed illustrative pictures of both processes. After reviewing the literature, we arrived to the conclusion that these entities are unusual when coinciding in one person, and they have not being reported in Cuba(AU)

Familial transmission of leprosy in post-war Britain--discrimination and dissent.

A Polish immigrant, who was resident in the United Kingdom (UK), presented with lepromatous leprosy and was detained in two hospitals against his wishes in the late 1940s. The public reaction to his diagnosis was remarkable, with street riots and questions in the Houses of Parliament about 'this leper'. His wife was persecuted and had to change her name. The index patient died of tuberculosis during enforced isolation in hospital, and several years later his daughter (who had never left the UK) presented with a left median nerve palsy and probable lepromatous dactylitis of the left third finger, eventually requiring amputation and prolonged dapsone treatment. Her disease resolved slowly but completely. We believe these two familial cases represent the first documented episode of autochthonous leprosy transmission in the UK since the early 1920s. They also demonstrate the ability of this disease to engender fear, dissent and discrimination amongst the public. Parallels are drawn with reactions to the cholera epidemics in nineteenth century Britain, and to HIV/AIDS, SARS and multi-drug resistant tuberculosis in more recent times.

Dermatología y literatura / Dermatology and literature

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Alteracoes palpebrais na hanseniase virchowiana de longa evolucao / ?

Foram examinados 128 pacientes hansenianos que compareceram ao ambulatorio de oftalmologia do Hospital "Dr. Francisco Ribeiro Arantes", e Itu, Sao Paulo, Brasil, no periodo entre 01 de junho de 1994 e 10 de julho de 1995. Destes, 110 (101 (91,82 por cento) de forma virchowiana (V) e 9 (8,18 por cento) da forma tuberculoide (T) foram incluidos no estudo. Colheram-se dados retrospectivos (a) identificacao: 1) Numero de registro; 2) Nome; 3) Data de nascimento; 4) Sexo; 5) Forma clinica da doenca; 6) Data de registro; 7) Tempo de evolucao da doenca; b) incapacidades: caracterizacao das incapacidades em maos, pes, nariz e presenca de paralisia facial periferica) e propectivos (altercaoes qualitativas (presenca ou ausencia de patologias, tais como

Eritema nodoso hansênico: conceitos gerais e novas perspectivas / Erythema nodosum leprosum: general concepts and new perspectives

Os autores fazem uma revisäo do eritema nodoso hansênico, no que concerne aos aspectos históricos, epidemiológicos, etiopatogênicos e clínicos, bem como fazendo referência aos diagnósticos diferenciais e as opçöes terapêuticas mais utilizadas

Tuberculosis in leprosy patients detected between 1902 and 1991 in French Polynesia.

From 1902 onward, notification and follow up of leprosy patients has been systematic in French Polynesia. Since 1960, a tuberculosis control program and a register has also been implemented. From 1902 to 1959, 673 cases of leprosy were detected [346 multibacillary (MB), 138 paucibacillary (PB), and 179 unclassified due to the loss of medical files by the time of classification which was done during the 1980s]. Of these 673 cases, 89 (13.2%) died from tuberculosis, giving a mean annual death rate of tuberculosis in leprosy patients of 232 per 100,000. Mortality from tuberculosis in leprosy patients detected between 1901 and 1930 was 20.7%, and decreased to 8.04% in patients detected from 1931 to 1959. In total, it was estimated that 26.4% of the leprosy cases had developed tuberculosis. From 1960 to 1991, 350 new cases of leprosy were detected (141 MB, 209 PB). Of them, 12 (3.4%) developed tuberculosis (7 before detection of leprosy, 5 after detection of leprosy). The dramatic decrease of the proportion of leprosy patients who developed tuberculosis between the periods 1902-1959 (26.4%) and 1960-1991 (3.4%) might be related to the important decline of the tuberculosis situation since 1960. From 1902 to 1959, mortality from tuberculosis occurred significantly more frequently in MB patients (13%) than in PB patients [4%, relative risk (RR) = 3.21, p = 0.003]. From 1960 to 1991, the incidence of tuberculosis seemed more frequent in MB patients (RR = 2.96, p = 0.07) whatever the sequence of detection of the two diseases. Our study suggests that lepromatous patients could share factors of susceptibility to mycobacterial diseases with patients developing tuberculosis.

Leprosy control in Zimbabwe: from a vertical to a horizontal programme.

In Zimbabwe leprosy control services were re-established in 1983, following the war of independence. Its main objectives were the nation-wide implementation of multiple drug treatment (MDT) and the integration of leprosy control into the general health services. The MDT regimens have led to a rapid reduction of the prevalence of leprosy. At the beginning of 1989 357 patients were on treatment and 1299 under follow-up. Six hundred and twenty-seven new cases have been detected since 1984, which represents an annual case detection rate of 1.6 per 100,000. This seems a fair reflection of the incidence rate, as the new cases are characterized by a minority of patients under the age of 15 (4%) and a lepromatous percentage of 50%. As the budget of the programme has remained unchanged integration of leprosy control into the general health services has become imperative. However, this transition is now hindered by a number of obstacles that were not foreseen at the start of the programme, because they are in measure corollaries of the successful implementation of MDT. Most of the problems that leprosy control is facing in Zimbabwe could have been avoided if instruction in leprosy had been introduced into the curricula of the (para) medical training schools 20 years ago.